8th CHRONIC HYPOXIA SYMPOSIUM

Oct 10 - 15, 2022     La Paz - Bolivia

SPEAKERS

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Prof. Dr. Gustavo Zubieta-Calleja  width=

Prof. Dr. Gustavo Zubieta-Calleja, M.D. FPVRI
Head of the High Altitude Pulmonary and Pathology Institute (HAPPI-IPPA)
Chairman
Vice-President of the International Society of Chronic Hypoxia
Ex-Visiting Professor University of Copenhagen
Visiting Professor BLDE University and Era University, India
The Hypoxia Man

Title: "Chronic Hypoxia: a remarkable stimulus for enhanced survival"

Chronic Hypoxia, Poly-erythrocythemia, Tolerance to Hypoxia, Altitude Adaptation formula, Oxygen Transport Triad, Pneumolysis, Low CoVID and other diseases at high altitude, Silent Hypoxemia, Extended Longevity at high altitude, Space travel in a hypoxic environment, Acid-Base high altitude correction factors, Bio-Engineering, High altitude Diving Tables, Chronic Mountain Sickness, Acute Mountain Sickness, Co-Organizer of the First World Congress on High Altitude Medicine and Physiology. Co-organizer of the 8th Chronic Hypoxia Symposiums, builder of the Chacaltaya Glass Pyramid Laboratory, Builder of the Hyperoxic/Hypoxic Adaptation Chambers Versions 1 and 2, Pulmonary function equipment construction, Co-organizer of the Futbol in Sajama at 6542m, Physician with expertise in high altitude medicine.

Thuppil Venkatesh

Prof. Thuppil Venkatesh, M.D.
Foundation for Quality India
President of the International Society of Chronic Hypoxia
Mountaineer and Scientist
The Lead Man of India

Title: "Beneficial effects of “PRANAYAMA” (regulated breathing) at high altitude hypoxic conditions – a new thought"
Title: "The International Society of Chronic Hypoxia: history and the future"

Dr Thuppil Venkatesh is a professor Emeritus at St John’s Medical College Bangalore. He is CEO and the Director of the Foundation for Quality India (FQI) and the Director of the National Referral Centre for Lead Projects in India (NRCLPI). Dr Thuppil is the current National Chairman of the Indian Society for Lead Awareness and Research (InSLAR) (www.inslar.org). He is also called as the Lead Man of India and was director of project Lead Free of The George Foundation which was instrumental in getting the unleaded petrol to India in March 2000. He served as the National Chairman in getting the Gazette notification for defining the limits for lead contents in paints. Dr. Venkatesh is also the Lead/Principal Assessor for the NABL & NABH under Quality Council of India (QCI). He is also the adviser to CAHO and AHPI. Served as an accreditation committee member for NABL, NABH, DAC Dubai and serving as the Chairman of Laboratory Accreditation Board of Nepal. Dr. Venkatesh is President of the International Society of Chronic Hypoxia and visiting professor of Zubieta University, Bolivia and Visiting Scholar of the University of Cincinnati, USA. He is the recipient of the International award for Science, Honor and Truth, prestigious Arya Bhatta Award apart from the life time achievement award from CAHO. He is also technical adviser to UNIDO and WHO. He has published over 350 scientific papers in peer reviewed journals.

Jan Marino Ramirez

Prof. Jan Marino Ramirez, PhD
Director of the Center for Integrative Brain Research
Head Laboratory of Vascular Physiology & Medicine
Seattle Children's Hospital
University of Washington
Seattle, USA

Title: "The role of intermittent and chronic hypoxia in the neuronal control of breathing and swallowing in health and disease"

Our studies focus on understanding the neuronal basis of a variety of brain functions to find novel ways to treat and cure neurological disorders in children, including epilepsy, Rett syndrome, brain tumors, and sudden infant death syndrome (SIDS). Our current work focuses on the analysis of the in vitro respiratory network in mice. For this purpose we isolate acutely the respiratory network in a transverse plane of the mouse medulla. This brainstem slice preparation contains the essential medullary structures involved in cardio-respiratory control and even after the in vitro isolation generates rhythmic activity in rats and mice of all developmental stages (up to an age of 25 postnatal days). This approach permits a direct comparison of the neuronal mechanisms of rhythmogenesis in newborn and more mature mammals. Our experiments indicate e.g. that the hypoxic response, fast chloride mediated inhibitory synaptic transmission, calcium channels and modulatory processes change postnatally within the respiratory network. He is recipient of the International award for Science, Honor and Truth,

Paolo Pelosi

Prof. Paolo Pelosi, M.D.
Chief Professor in Anaesthesia and Intensive Care,
Head of Anaesthesia and Intensive Care Unit at IRCCS San Martino-IST Head of the Anaesthesia and Intensive Care Unit
Genoa, Italy

Title: "Hypoxia, normoxia and hyperoxia: what have we learned from critically ill patients?"

Vincent Joseph

Prof. Vincent Joseph, PhD
Professor of Physiology Laval University
Departement de Pediatrie, Universite Laval
Quebec, Canada

Title: "Metabolic responses to intermittent hypoxia are modulated by sex hormones in male and female mice"

Protective roles of sex-hormones in respiratory and metabolic disorders induced by intermittent hypoxia in male and female mice. Metabolic and respiratory responses to acute, chronic, or intermittent hypoxia, from the whole animal down to cellular energetics. Characterization of mice and rats as divergent models of adaptation and acclimatization to chronic hypoxia. Developmental plasticity induced by chronic or intermittent hypoxia in newborn rodents.

Kusal Das


Kusal K Das PhD FRSB(UK)
Professor
Laboratory of Vascular Physiology and Medicine
Department of Physiology
Shri B.M.Patil Medical College
BLDE (Deemed to be University)
Vijayapur-586103, Karnataka, INDIA

Title: "Neuroprotective effect of Mucuna Pruriens derived β-Sitosterol preconditioning on cerebral ischemic rats"

My Laboratory of Vascular Physiology & Medicine works on understanding of vascular diseases through their complex mechanisms. My works devoted to shape vascular integrity and find out some innovative approaches which may improve the quality of human life or sufferings. I have made some impact contributions on understanding of experimentally induced hypoxia and cell signaling mechanism during heavy metal induced stress and alteration of vascular integrity using an animal as well as human models. My works also extended to cerebral ischemia in experimental models. He is the recipient of the International award for Science, Honor and Truth,

Hari Sharma


Prof. Hari S. Sharma PhD, DSc, FIABS, FIEIC
Pathology & Clinical Bioinformatics
Erasmus University,
Rotterdam, Netherlands

Title: "Molecular Mechanisms of Hypoxia induced Collateralization in the Heart: Lessons from a porcine model"

A dedicated Biomedical Teacher and Researcher in Molecular Pathology of Vascular & Tissue Remodeling in Cardiac-Pulmonary Diseases Disciplines Molecular BiologyCell Biology Skills and expertise Cloning PCR Gene Expression Cancer Biology Northern Blot mRNACell Culture ELISA Western Blot DNA Stem Cell Biology Pharmacology Molecular Biology Biochemistry Cell Biology Proteins RNA Cardiac Hypertrophy Sequencing Angiogenesis Endothelial Cells Transcription Factors Molecular Cloning Gel Electrophoresis Gene Regulation Electrophoresis RNA Analysis Molecular Genetics Western Blot Analysis Regulation of Gene Expression Genetic Engineering DNA Sequencing Transcription RNA Interference RNA Extraction SDS-PAGE mRNA Expression cDNA Protein Purification Reverse Transcription DNA Analysis Promoter Analysis RNA Biology Lung Pulmonary Hypertension Asthma Drought Stress Smooth Muscle Heat Stress Serotonin Arteries Extracellular Matrix Proteins RNA Isolation Cells

Jorge Soliz


Dr. Jorge Soliz, PhD
Full Professor,
CR IUCPQ/ Universite Laval.
Dpt Pediatrie,
Quebec, Canada

Title: "Impact of erythropoietin on the carotid bodies: sexual dimorphism and chronic mountain sickness"

Disciplines PhysiologyNeuroscienceMolecular Biology Skills and expertise Ion Channels Pharmacology Physiology Neuroscience Electrophysiology Vascular Diseases Angiogenesis Hypoxia Animal Physiology Molecular Biology Patch-Clamp Electrophysiology Neurophysiology Neurobiology and Brain Physiology Ventilation Oxidative Stress Patch-Clamp Techniques Animal Anatomy Biochemistry Neurobiology Nitric Oxide Hypertension Genetics

Jorge Salazar Bravo


Dr. Jorge Salazar Bravo, PhD
Associate Professor
Biological Sciences and Director,
International Center for Arid and Semi-Arid Lands Studies
Texas Tech University Lubbock, TX 79409

Title: "Andean rodents: evolution and high elevation adaptations"

Disciplines Virology Skills and expertise Small Mammals Systematics Evolution Molecular Phylogenetics Biodiversity Phylogeography and Phylogenetic Biogeography

Christian Arias-Reyes


Christian Arias Reyes , PhD. (c)
Faculty of Medicine. CR
IUCPQ/ Universite Laval.
Quebec, Canada

Title: "Chronic hypoxia triggers mitochondrial plasticity in the brain of mice, but not in rats"

Metabolic cell and mitochondrial mechanisms of acclimatization to hypoxia. Always in a wider field of the study of life in high altitude. Disciplines Physiology Evolutionary Biology Molecular Biology Skills and expertise Biomedical Science Cell Culture Gel Electrophoresis Electrophoresis DNA Extraction SDS-PAGEATP Translocases Mitochondrial ADP Plethysmography Reactive Oxygen Species Oxidative Stress High Resolution Respirometry

Edith Schneider Gasser


Dra. Edith M. Schneider Gasseer, PhD
Institute of Veterinary Physiology, Vetsuisse-Faculty,
University of Zurich,
Zurich, Switzerland,
Center for Neuroscience Zurich (ZNZ),
Zurich, Switzerland

Title: "Sexual dimorphism in the brain metabolism at high altitude"

Currently works at the Institut of Veterinary Physiology at the University of Zurich. Edith does research in Neuroscience. Their current project is 'Role of erythropoietin in brain development‘ Disciplines Neuroscience Skills and expertise Patch-Clamp Electrophysiology Synapses Presynaptic Terminals Electrophysiology Neuron-Glia Interaction Neuron Immunostaining Real-Time PCR Neuroscience Cognitive Development Patch Clamp Recording Neurophysiology Immunoprecipitation Virus Transgenes Immunofluorescence Neurobiology Hippocampus GABA Monoclonal Antibodies Patch-Clamp Techniques

Lata Mullur


Prof. Lata Mullur, PhD
Professor
Laboratory of Vascular Physiology and Medicine
Department of Physiology
Shri B.M.Patil Medical College
BLDE (Deemed to be University)
Vijayapur-586103, Karnataka, INDIA

Title: "Vitamin D influences cardiovascular diseases – Role of VEGF"

Disciplines Allied Health Science Skills and expertise Yoga Cardiovascular System

Shrilaxmi Bagali


Prof. Shrilaxmi Bagali, PhD
Professor
Laboratory of Vascular Physiology and Medicine
Department of Physiology
Shri B.M.Patil Medical College
BLDE (Deemed to be University)
Vijayapur-586103, Karnataka, INDIA

Title: "Sympathovagal imbalance drives the chronic sustained hypoxia induced impairment of glucose homeostasis in normobaric experimental rats. Role of L/N type calcium channel blocker (cilnidipine)"

Pulmonology Cardiology Respiratory Medicine Skills and expertise Hypoxia Oxidative Stress

Natalia Zubieta-DeUrioste


Dra. Natalia Zubieta-DeUrioste, M.D.
High Altitude Pulmonary and Pathology Institute (HAPPI-IPPA)
La Paz, Bolivia
PHD candidate
University of Calgary,
Calgary, Canada

Title: "Lower Case Fatality Rate of COVID-19 in cities above 2,500m in Bolivia, Ecuador, Colombia, Peru and Mexico"

Chronic Hypoxia, Poly-erythrocythemia, Tolerance to Hypoxia, Altitude Adaptation formula, Oxygen Transport Triad, Pneumolysis, Low CoVID and other diseases at high altitude, Silent Hypoxemia, Extended Longevity at high altitude, Space travel in a hypoxic environment, Chronic Mountain Sickness, Acute Mountain Sickness, Co-organizer of the 6th 7th and 8th Chronic Hypoxia Symposiums, co-Builder of the Hyperoxic/Hypoxic Adaptation Chamber Versions 2, Pulmonary function, Physician with expertise in high altitude medicine.

Abbas Ali Mahdi


Prof. Abbas Ali-Mahdi, PhD, FIABS, FAMS
Head of Department Biochemistry
King Georges's Medical University
Former Vice-Chancellor
Era University,
Lucknow, India

Abbas Ali Mahdi currently works at King George’s Medical University, Lucknow. He was Vice Chancellor, Era University, Lucknow (India) for two years, between September 2017 – 2019. His areas of research interest are mainly free radical biology, medical elementology & toxicology and natural products. He has more than three decades of research and teaching experience with 350 research publications including 40 book chapters with over eleven thousand citations. Disciplines Biology Medicine Skills and expertise Inflammation Lipid Peroxidation Plasmodium Spermatogenesis Biology Medicine Glutathione Peroxidase Antioxidant Activity Metabonomics Reactive Oxygen Species Free Radicals1H-NMR Triglycerides Nutrition

Sinerik Ayrapetyan


Prof. Sinerik Ayrapetyan, PhD
Chair at Life Sciences International Postgraduate Educational Center
UNESCO Chair in Life Sciences
UNESCO/UNITWIN Interregional NETWORK in Biophysics, Biotechnology and Environmental Health Yerevan, Armenia

Title: "The dysfunction of Na/K pump driving water efflux from the cells as a primary mechanism for cell pathology"

Current research: Physiology of weak chemical and physical signal transductions in cells. The role of cell hydration in the realization of biological effects of these signals. The role of Na/K-ATPase alpha isoforms in the above mentioned. Cancer Biology Cell Signaling Cancer Therapy Neurotransmitter GABA Neuron Ecology Cancer Chemotherapy Kinase Receptor Mechanical Vibrations Brain Phosphorylation Water Apoptosis Teaching and Learning Physiology Pharmacology Cancer Research Signal Transduction Signaling Pathways Electromagnetic Fields Membranes Cell Culture Magnetic Field Immunohistochemistry Protein Kinases Cell Migration PCR Flow Cytometry RAS Cell Proliferation Cancer Biomarkers Acetylcholine Stomatology Western Blot Analysis Muscle Sodium In Vivo Imaging Animals Microorganisms Rats Biotechnology Dehydration Incubation Hydrogen Peroxide cAMP cGMP Receptors Voltage Clamp Ganglia Lectins Cellular Biophysics Membrane Biophysics Glutamate Project Management ATP Molecular Biology Life Sciences Cancer Cell Biology

Roberto Accinelli


Dr. Roberto Accinelli Tanaka, M.D.
Previous Director Instituto de Investigaciones de la Altura,
University Cayetano Heredia,
Lima, Peru

Title: "Asthma at high altitude"

Pulmonologist, COVID specialist, Anemia at high altitude

Malali Gowda


Prof. Malali Gowda, PhD
Founder and Head Bangalore Genomics Center
Founder adn Head DNA Life
Bangalore, India

Vasanth Rao


Vasanth Rao
President Founder Trustee, Motor-Neuron Disease Trust-
Dr. Shyama Narang Foundation
Bangalore, India

Title: "Hypoxia possible frontier for treatment for Motor Neuron Disease (MND)"

Founder Trustee: Dr. Shyama Narang Foundation [MND Trust]– a registered Nonprofit Trust established with the goal to find a cure for Motor Neurone Disease (MND) through coordinated efforts of clinicians, scientists, pharmaceutical companies, NGOs and other stakeholders to accelerate research and development. Till such time the Foundation will support people with MND and their caregivers with information and guidance so as to enable them to stay connected with their families and communities.

Johan Kofstad


Prof. Johan Kofstad, M.D. PhD
former Chief Department of Medical Biochemistry Rigshospitalet
Chairman of the Norwegian Mountain Medical Society
Oslo, Norway

Title: "The Norwegian Mountain Medical Society and Acid-Base at extreme altitudes"

Santiago Ucros


Prof. Santiago Ucros M.D. PhD
Department of Pediatrics,
Pediatric Respiratory Medicine.
Fundacion Santa Fe de Bogota
Bogota, Colombia

Title: "Oxygen saturation parameters and apnea/hypopnea index in children at high altitude"

Santiago Ucros currently works at the Department of Pediatrics, Fundación Santa Fe de Bogota. Santiago does research in pediatric respiratory medicine; infants and children sleep physiology at high altitude; infant/sleep oxygen saturation at high altitude; high altitude pulmonary edema; sudden infant death syndrome at high altitude; post infectious bronchiolitis obliterans in Colombia; primary cilialry dyskinesia in Colombia; acute respiratory infection seasonality in Colombia. Currently working in poligraphy and CO2 values in healthy children from 4-8 years of age at 2600 meters above sea level; oxygen saturation meta-analysis in infants/children at high altitude.

Jorge Velez


Prof. Jorge Luis Velez M.D. MSc. PhD
Head of Department Critical Medicine
Central University of Ecuador
Pablo Arturo Suarez Hospital
Quito, Ecuador

Title: "Obesity and Hypobaric Hypoxia, allies in survival of COVID-19"

At the moment managing patients with COVID-19 in critical condition. All current research at my center is focused on the pandemic. Disciplines Internal Medicine (General Medicine) Respiratory Medicine Infectious Diseases Skills and expertise Internal Medicine Evidence Based Medicine Critical Care Medicine Septic Shock Sepsis Mechanical Ventilation Hemodynamics Intensive Care Medicine History of the Medicine, Translational Medicine

Marketa Hlavackova


Prof. Marketa Hlavackova; PhD
Laboratory of Developmental Cardiology
Institute of Physiology of the Czech Academy of Sciences
Prague, Czech Republic

Title: "Effect of chronic hypoxia on epitranscriptomic machinery in the heart"

Her research concerns the molecular mechanism underlying the long-lasting cardioprotective and antiarrhythmic effects conferred by adaptation to chronic continuous and intermittent hypoxia, regular exercise training, and dietary intervention. More recently, she became interested in the role of mass and obesity-associated (FTO) protein in cardiac tolerance to ischemia-reperfusion injury and the role of FTO activity in the long-term early programming and regulation of cardiac function and energy metabolism under normal and adverse perinatal conditions.

Praveen Sharma


Prof. Praveen Sharma PhD,FACBI,FAMS,FAACC
Professor and Head,
Biochemistry
All India Institute of Medical Sciences, Jodhpur
Jodhpur, India

Chief editor of Indian Journal of Biochemistry. Biomarkers Clinical Biochemistry Medical Biochemistry Antioxidant Activity Clinical Oncology Free Radicals Insulin Resistance Obesity Vitamins Physiology Vitamin C levels and diseases Vitamin C Inflammatory Biomarkers Diabetes Metabolic Syndrome Metabolism Glycation Beta Cell Cholesterol Triglycerides Antioxidants Coronary Artery Disease Dyslipidemia Lipids Atherosclerosis Gold Oxidative Stress Lipoproteins Glutathione Risk Factors Cardiovascular Disease Diabetes Mellitus Diabetes Mellitus Type 2 Insulin Cardiovascular Risk Blood Pressure LDH Biomarker Discovery High Density Lipoproteins (HDL) Metabolic Diseases Lipid Metabolism Hypertension Ascorbic Acid

Walter Calderon-Gerstein


Prof. Walter Calderon Gerstein M.D.
Universidad Continental de Ciencias e Ingenieria
Huancayo, Peru

Title: "Endothelial function at high altitude"

Diabetology Internal Medicine (General Medicine) Cardiology Skills and expertise Heart Failure Atrial Fibrillation Cardiac Function Chronic Heart Failure Clinical Cardiology Electrocardiography Blood Pressure Internal Medicine Clinical Physiology

Jose Antonio Carmona


Dr. Jose Antonio Carmona M.D.
Universidad Nacional Autónoma de México
México City, México

Title: "Searching for the invasive and non-invasive cerebral oxygenation threshold in acute brain injuries at altitude"

Intensive care Neurocritical care Critical Patient Workshops of neurocritical care México

Hamid Mobasheri


Prof. Hamid Mobasheri PhD
UNESCO/UNITWIN
Department of Environmental Health
Network Biophysics Coordinator
Head of Laboratory of Membrane Biophysics and Macromolecules
University of Tehran
Tehran, Iran

Title: "Biophysical effects of high altitude on the susceptibility of the living cells to corona virus infection"

His current project is 'The effect of static magnetic fields on neural communication and microtubule organization.' His team tries to understand the biophysical susceptibility of biological systems to magnetic, electric and electromagnetic fields at molecular, cellular and tissue levels. The ultimate aim is to find out the fields' side effect and to apply them as a manipulative means to monitor and tackle cell abnormalities, diseases and pathogenic microorganisms. In summary, he is interested in the physics of cell machinery involving ions, electrons, protons, radicals etc. whose actions are manifested by bioresonance, bioelectronics, bioelectrics, bioimpedance and Bio-nanotech.

Aurio Fajardo


Dr. Aurio Fajardo Campoverdi, M.D. MSc. MEC. PhD(c)
Head of Respiratory Care Unit,
Hospital de Quilpué
Head of Respiratory Care Team,
Hospital de Quilpué,
CEO of WeVent (International Mechanical Ventilation group)
Member of the Expert Committee of Mechanical Ventilation (FEPIMCTI)
Member of the American Association for Respiratory Care (AARC)
Vina Del Mar, Chile

Title: "Comparison of the real pneumatic performance offered by high-flow oxygen therapy and non-invasive ventilation devices: a bench study"

MSc Mechanical Ventilation Internal Medicine (General Medicine) Emergency Medicine Respiratory Medicine Skills and expertise Respiratory Physiology Mechanical Ventilation Critical Care Medicine ICU Intensive Care Medicine Ventilation Respiratory Mechanics

Rodrigo Hernan tomas Grau


Dr. Rodrigo Hernan Tomas Grau, PhD
Post-Doc
IMMCA
Instituto de Investigación en Medicina Celular y Molecular Aplicada
(CONICET-UNT-SIPROSA). Tucuman, Argentina

Title: "Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD ′In-House′ ELISA"

Molecular Biology Neuroscience Biotechnology Skills and expertise Fluorescence microscopy - Fluorescence microscopy Purification Liquid Chromatography Histochemical Assay PCR Protein Purification Parkinson's Disease Fluorometry Alzheimer's Disease Tetracycline Hit to Lead In Vitro Pharmacology

Antonio Viruez Soto


Dr. Antonio Viruez, MD
Master in Bioethics
Head of the Critical Care Department, Hospital del Norte, El Alto-La Paz, Bolivia
     President of the Scientific Committee of the Bolivian Society of Critical Medicine and Intensive Care, Filial La Paz
Director of the Department of Critical Medicine of the Latin American Thoracic Association
El Alto, Bolivia

Title: "Low Serum Erythropoietin Levels are Associated with Fatal COVID-19 Cases at 4,150 meters above sea level"

Respiratory Medicine Anaesthetics Emergency Medicine Intensive Care Medicine Critical Care High Altitude Critical Care Medicine Mechanical Ventilation ICU Airway Management Sepsis Ventilation

Jose A. Castro-Rodriguez, MD. PhD. ATSF


Dr. Jose A. Castro-Rodriguez, MD. PhD. ATSF
Full Professor
Pediatric Pulmonologist
School of Medicine
Pontificia Universidad Catolica de Chile
Santiago, Chile

Title: "High Altitude Pulmonary Edema in Children: A systematic Review"

MPH Pharmacology Public Health Nursing Allergy Asthma Asthma Research Allergic Diseases Spirometry Asthma Management Allergens Allergic Rhinitis Pulmonary Function Test Cost-utility analysis Allergic Asthma Community Health Nursing Economic Evaluation Lung Diseases Respiration Disorders Systematic Reviews Meta-Analysis Cystic Fibrosis Chronic Obstructive Pulmonary Disease Airway Obstruction

Maximo Liberman


Lic. Maximo Liberman
Biologo
Full Professor
Instituto de Ecologia,
Facultad de Ciencias Puras y Naturales
Universidad Mayor de San Andres, La Paz Bolivia

Title: "The life of Alpaca shepherds above 4,800 m in Apolobamba, Bolivia in the Andean Mountain Range within the climate change context"

Emeritus Professor Maximo Liberman Cruz, biologist, teacher and researcher of the Ecology Institute at the University of San Andres, in La Paz Bolivia. He studied at the University of Concepción, Chile. Graduated in rural studies at ITC, Enschede, The Nederlands. Visiting Professor at the University, Los Andes, Merida Venezuela, at the Environmental Management Course. Visiting professor of Biogeography and Vegetation of South America course at the University of Camerino, Italy. He has numerous scientific papers and six books published in Bolivia and USA related to: Desertificatión in Bolivia, Land Use Change and Mountain Biodiversity, Land use and Biodiversity Resources in Protected Areas of Bolivia, and Sustainable development of Fragile Ecosystems in the Andean Mountains.

Andrea Marengo


Dr. Andrea Marengo, M.D.
Clinical Neurologist
Hospital Alfredo Perrupato.
Mendoza, Argentina

Title: "Trombosis Venosa Cerebral con transformación hemorrágica a los 6050 msnm en el cerro Aconcagua - Mal de Montaña" Title: "Escaladores sanos con lesion axonal periferica por altitude determinada por estudios de neuroconduccion"

Neuróloga clínica/ Especialista en Cefaleas /Médica de Montaña/FCM - Universidad Nacional de Cuyo/ Doctorando en Medicina/ en Hospital Alfredo Perrupato/ Mendoza/ Argentina.

silvia Zambrana


Dr. Silvia Zambrana, PhD
Biologist
Instituto de Investigaciones Fármaco Bioquímicas, Universidad Mayor de San Andrés
La Paz, Bolivia

Title: "HIF-1 mediated activation of antimicrobial peptide LL-37 in type 2 diabetic patients"

Molecular & Cellular Biology, Immunology,Pharmacology, Mammalian Cell Culture, Natural Products

tom Brusaert


Prof. Tom Brutsaert, PhD
Exercise Physiology
Anthropology Dept
Falk College
Syracuse University
New York, Washington D.C., USA

Title: "Factors affecting the exercise performance of highland natives in the Andes and Himalayas"

Human biology, high-altitude adaptation, physical activity, growth and development.Professor Brutsaert has broad interests in how gene and environment interact to produce variation in human athletic ability and health and disease. He conducts field research on high altitude natives in the Andes, with some focus on gas exchange and the control of breathing. He and his collaborators have been using genome-wide approaches to elucidate the genetic basis of variation in specific altitude adaptive traits in several Andean populations, including the Quechua, in Peru, and the Aymara, in Bolivia. Brutsaert also has a laboratory-based program that focuses on how early life (intrauterine) developmental effects influence later-life adult exercise capacity, physical activity, body composition, the response to training, and the future risk for chronic disease. Several projects in this area have been conducted with US college-aged students and with rural children in Costa Rica. For the latter, the interest is in whether early life conditions program physical activity patterns and muscle function during childhood. In addition to his research interests, Brutsaert helps to coordinate the Human Performance Laboratory (HPL) at Syracuse University, and is the director of the Altitude Simulation Laboratory (ASL). The ASL houses a human-scale hypoxia chamber that is large enough to accommodate several test subjects and investigators during metabolic and/or exercise testing under simulated altitude conditions up to 20,000 feet. Brutsaert holds a courtesy appointment in the Department of Anthropology and collaborates with faculty at the SUNY Upstate Medical Institute of Human Performance (IHP) which houses clinical facilities and advanced imaging and muscle function technologies.

Felipe Montelongo


Prof. Felipe de Jesús Montelongo, MD
Head of the Intensive Care Unit
Hospital Las Américas de Ecatepec
Ecatepec, Mexico

Title: "COVID-19 intra-cellular replication; histopathological and immune alterations at 2,500m"

-Jefe de Áreas Críticas del HGE Las Américas. ISEM. México -Profesor por oposición de catedra de la Escuela Nacional de Medicina. IPN. -Profesor titular de las residencias de Medicina Critica. UAEM. -Profesor internacional del World Interactive Network Focused on Critical Ultrasound (WINFOCUS). -Director del primer centro de entrenamiento, investigación y formación en competencias de Ultrasonografia en Medicina Crítica, en México. -Creador de diversas técnicas ultrasonograficas en México. -Creador del Código Mater, como estrategia para disminuir la morbimortalidad materna, con registro público de derechos de autor, con el No. 03-2012-072313014301-01, actualmente lineamiento técnico federal, en México. -Miembro dictaminador del comité interinstitucional de morbimortalidad materna del Estado de México. -Asesor nacional para la disminución de la mortalidad materna en México. CSG. -Perito en medicina critica 722 PJF.

Rodrigo Soria Maldonado


Dr. Rodrigo Soria Maldonado
Department of Cardiology and Clinical Research,
Inselspital,
University of Bern, Switzerland

Title: "Pulmonary arterial pressure at rest and during exercise in chronic mountain sickness"

Research Assistant. I studied medicine at Higher University of San Andrés. After my studies I got an scholarship from the Swiss government. I did a research fellowship in the Cardiology Research group from Prof. Allemann and Prof. Scherrer at University Hospital “Inselspital” in Bern. Followed by a doctoral program under the supervision of Prof. Rimoldi at the University of Bern. The main topic of my studies was pulmonary hypertension and underlying mechanism in chronic mountain sickness. I had a close collaboration and support from the epidemiologist, Prof. Egger and Prof. Bender from the Institute of Social and Preventive Medicine. Currently, I am working as a research assistant in the Cardiology research group of Dr. Rexhaj and our main studies is on cardiovascular function in people were born after assisted reproductive techniques.

Theo Meister


Dr. Théo Meister
Department of Cardiology and Clinical Research,
Inselspital,
University of Bern, Switzerland

Title: "Sleep-disordered breathing and vascular function in Chronic Mountain Sickness"

HanneloreEhrenreich


Dr. Hannelore Ehrenreich, MD, DVM
Professor of Neurology and Psychiatry
Prof. Hon. of Biology & Psychology
University of Göttingen
Clinical Neuroscience
Max Planck Institute for Multidisciplinary Sciences
Göttingen, Germany

Title: "Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance"

Clinical Neuroscience (1) Genetic and environmental underpinnings of neuropsychiatric diseases; (2) Endogenous neuroprotection and neuroregeneration as therapeutic strategies for patients: Research centering on the brain erythropoietin system and hypoxia; (3) Autoimmune and inflammatory processes contributing to neuropsychiatric phenotypes.


Natalia Aralova


Dr. Natalia I. Aranova, PhDDSc (Engineering)
Senior Researcher Optimization of Controlled Processes,
Glushkov Institute of Cybernetics of National Academy of Sciences of Ukraine,
Kiev, Ukraine

Title: "Dynamics of the functional respiratory system parameters under the influence of mountain meteofactors. Research at the Elbrus Medical-Biological Station"

PhD, ScD (Eng). Interests are related to the study of human life in extreme conditions, development and analysis of mathematical models and algorithmic support of the functional human respiratory system in case of disturbances of the external and internal environment, research of reliability, resistance and processes of human adaptation to hypoxic states of various etiologies. Separate directions — transport of respiratory gases through the respiratory and circulatory systems, mental and physical performance of a person during a stay in the highlands, under conditions of increased situational stress. participated in the research and selection of Soviet and Ukrainian climbers who climbed the Himalayan peaks, studied the effect of radiation on the human body, developed methods of treatment and rehabilitation of the irradiated.

Carsten Lundby


Prof. Carsten Lundby, PhD
University of Lillehammer
founder at Detalo Health ApS
Lillehammer, Norway

Title: "Regulation of blood volume at high altitude?"

Prof. Carsten Lundby is an internationally renowned scientist who has published +200 scientific articles. His main interest is within human physiology and how humans adapt to external stimulus such as exercise, altitude, heat, physical activity and bed rest. Main topics within basic physiology includes the regulation and assessment of blood volume. He has lead clinical trials within kidney failure. He is member of a number of editorial boards for scientific journals and serves on international commissions. Carsten has extensive experience within medical device development and certification and is the CEO of the MedTech company Detalo Health. Carsten does outdoor sports approximately 350 days/ year.

Graham Scott


Dr. Graham Scott, PhD
Associate Professor
Canada Research Chair
Department of Biology
Comparative & Evolutionary Physiology
McMaster University
Hamilton, Ontario, Canada

Title: "Respiratory adaptations to high altitude and their genetic basis in deer mice"

Our lab strives to understand how the respiratory and metabolic systems of vertebrates adjust to challenging environments and how they adapt over evolutionary time. We use a comparative evolutionary approach in mammals, birds, and fish to understand the mechanistic basis for variation within and between vertebrate groups. Integrative approaches explore the causal links between levels of organization – from gene/genome to physiological system to organism. Some of our ongoing projects are discussed below. If you'd like to learn more, check out our Publications page where you can find links to various journal articles and features in the popular media

Tammie Bishop


Dr. Tammie Bishop, PhD
University Research Lecturer
Hypoxia and Cancer
Nuffield Department of Medicine
Comparative & Evolutionary Physiology
University of Oxford
Oxford, England

Title: "HIF-2 and the carotid body"

My research interests are in understanding the role of hypoxia in cancer. Specifically, we are interested in defining the circumstances and molecular pathways by which hypoxia and hypoxia signalling directly promote cell proliferation. Genetic mutations of hypoxia/HIF signalling pathway components are commonly associated with certain types of cancer e.g. carotid body paragangliomas, adrenal medullary pheochromocytomas, kidney clear cell carcinomas and understanding the mechanisms involved may help with treatment of these cancers. We have shown that Type I cells in the carotid body proliferate in response to hypoxia and that this (like VHL-associated kidney cancer) is dependent on a specific isoform of HIF, HIF-2alpha (Fielding et al., 2018; Hodson et al., 2016). Further, we have shown that unrestrained activation of HIF-2alpha in the mouse carotid body leads to a paraganglioma-like growth (Fielding et al., 2018), mimicking the human genetic condition and providing the first such mouse model to explore the mechanisms and potential therapeutic treatments of this and other HIF-2 dependent cancers.

Felix Loza


Dr. Victor Feliz Loza Chacón, MD
Cardiologist
Hospital de Clínicas Universitario de La Paz
Professor of Cardiology
Universidad Mayor de San Andrés
Founder and President of the Asociación Boliviana de Aterosclerosis
La Paz, Bolivia

Title: "Hypertension and myocardial infarction at high altitude, what is the truth??"

Médico cardiólogo de planta de la unidad de Medicina Primera del Hospital de Clínicas Universitario de La Paz, Bolivia, docente titular de la cátedra de cardiología de la Facultad de Medicina de la UMSA; diplomado en Educación Superior, ex Director del Hospital de Clíicas Universitario La Paz, Bolivia. Miembro Titular y fundador de ASOBAT (Asociación Boliviana de Aterosclerosis), Presidente en ejercicio de ASOBAT

Giuseppe Miserocchi


Prof. Giuseppe Miserocchi, MD
Former Prof. of Physiology and Biophysics
Università degli Studi di Milano – Bicocca
Italia

Title: "The ′safety factors′ protecting against the development of lung edema; a functional interpretation of pulmonary hypertension"

Efficiency and downregulation of the respiratory function when facing the oxygen demand: from mechanics and gas exchange to energy yielding. Respiratory Medicine Hypoxia High Altitude Pulmonology


Vania Garcia


Dr. Vania Garcia, MD
Ophtalmologist Surgeon
Sub especialist in Retina and images Director
Centro Oftalmologico Vision21
Universidad de Chile
Universidad Mayor de San Andrés
La Paz, Bolivia

Title: "Relationship of geographic altitude with Fovela Avascular zone Metrics and Vascular Density Assessed by OCT Angiography"

Dr. Shashi Bala Singh


Dr. Shashi Bala Singh
Director
National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad
Was Distinguished Scientist and Director General (Life Sciences) at DRDO HQs

Fellow of National Academy of Medical Sciences (FNASc)
and Indian Academy of Neurosciences (FIAN)
New Delhi, India

Title: "HDAC inhibition Prevent Hypobaric Hypoxia Induced Neurodegeneration and Memory Impairment"

Using translational research for improving life of troops at high altitude, her endeavors have made the life of troops comfortable in the most difficult-to-inhabit terrains. During her tenure as Director at Leh, she created an innovative agricultural eco-system that has enabled the socio-economic development of Ladakh via science and technology. Under her guidance, various technologies/products like oxygen-enrichment facilities, Sourja (solar shelter), Bukhari, Alocal (for frost-bite) were improvised. She has been instrumental in customizing various yoga packages for high altitude and hot desert conditions

Dr. Carlo Vercosa


Dr. Carlo Vercosa
Instituto Nacional Del Torax,
La Paz, Bolivia

Title: "Pulmonary hypertension at high altitude"


Dr. Alfredo Merino


Dr. Andres Alfredo Merino
Residente de 1er año de Cuidados Intensivos
Miembro del Grupo de Investigación de Medicina Intensiva en Altura ( GIMIA)
Bombero Voluntario de la Compañía de Bomberos La Molina 96
Divemaster de Buceo PADI
San Salvador, El Salvador

Title: "Higher levels of cytoquines in COVID-19 patients at high altitude as compared to sea level"


Dr. Jose Manuel Calle


Dr. José Manuel Calle
Médico neumólogo
Universidad Tomas Frias
Hospital Daniel Bracamonte
Potosi, Bolivia

Title: "COVID-19 en Potosi a 4000 metros sobre el nivel mar"


Dr. Favio Muñoz


Dr. Favio Muñoz
Medico
Centro de Instrucción de Buceo De Altura
Armada Boliviana
Titicaca Lake
Tiquina, Bolivia

Title: "Efectos de la medicina hiperbarica en pacientes con anemia moderada a severa como terapia alternativa de tratamiento a 3810 metros sobre el nivel de mar"


Dr. Gulnura Dzhunusova


Dr. Gulnura Dzhunusova M.D.
professor
head of the laboratory of neurophysiology
director of the Institute of mountain physiology and medicine
of the National academy of sciences of the
Kyrgyz Republic

Title: "HUMAN ADAPTATION TO HIGH MOUNTAIN CONDITIONS AT THE ALTITUDE OF 2800 M ABOVE SEA LEVEL"

The main direction of research is the study of the neurophysiological mechanisms of human adaptation under the influence of extreme and mountainous environmental factors, the assessment of the functional state of a person in order to predict their activities in extreme and high-mountain environmental conditions, the identification of disadaptive and functional disorders and their correction by adaptive biofeedback.


.IPPA
HIGH ALTITUDE PULMONARY AND PATHOLOGY INSTITUTE
La Paz, Bolivia (3500 m)

You can contact us at zubieta@altitudeclinic.com 

 


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